GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs965513 | 1 | rs4743131 | chr9:100554907 | EPDR1 | chr7:37960163-37991539:+ | 0.32 | 7.17 | 2.86E-12 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs4743131 | chr9:100554907 | GGT5 | chr22:24615623-24641110:- | 0.26 | 5.98 | 4.48E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs4743131 | chr9:100554907 | LRRC42 | chr1:54412037-54433839:+ | -0.23 | -5.96 | 4.79E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs4743131 | chr9:100554907 | NKX6-1 | chr4:85414436-85419387:- | 0.48 | 8.35 | 7.4E-16 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs4743131 | chr9:100554907 | PLCE1 | chr10:95753746-96088146:+ | 0.27 | 6.07 | 2.66E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs877636 | 1 | rs4759229 | chr12:56474480 | RPS26P11 | chrX:71264259-71264809:+ | -0.51 | -9.13 | 1.91E-18 | Cognitive function |
| THCA | trans | rs501120 | 1 | rs479596 | chr10:44760473 | TWISTNB | chr7:19735085-19748660:- | -0.33 | -5.99 | 4.25E-9 | Coronary artery disease;Coronary heart disease |
| THCA | trans | rs6600671 | 1 | rs4844380 | chr1:121193620 | NBPF14 | chr1:148003643-148346791:- | 0.42 | 10 | 1.71E-21 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs4844381 | chr1:121184898 | NBPF14 | chr1:148003643-148346791:- | 0.43 | 10.4 | 5.75E-23 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs4844607 | chr1:121184059 | NBPF14 | chr1:148003643-148346791:- | -0.42 | -10.02 | 1.44E-21 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs4844616 | chr1:121171208 | NBPF14 | chr1:148003643-148346791:- | 0.44 | 10.48 | 2.83E-23 | Hip geometry |
| THCA | trans | rs1056667 | 1 | rs4871 | chr6:26545632 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.3 | 1.3E-22 | Educational attainment |
| THCA | trans | rs5751901 | 1 | rs5751901 | chr22:24992266 | GGTLC2 | chr22:22988782-22990368:+ | -0.26 | -6.12 | 1.92E-9 | Protein quantitative trait loci |
| THCA | trans | rs1056667 | 1 | rs6456733 | chr6:26566804 | ZNF322B | chr9:99957633-99961910:- | 0.59 | 11.41 | 7.49E-27 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs6456734 | chr6:26566965 | ZNF322B | chr9:99957633-99961910:- | 0.59 | 11.41 | 7.49E-27 | Educational attainment |